keroncrowd.blogg.se - Yasu shibata

Some GPCRs are not subject to this type of desensitization because they lack the residues required to interact with β-arrestins.

13 Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.Īfter ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane.

12 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

11 Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.

10 Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.

9 Department of Biological Sciences, Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan.8 Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Osaka 598-8531, Japan.7 Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1-H-101, Ookayama, Meguro, Tokyo 152-8552, Japan.6 Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.

5 Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.4 Department of Physiological Sciences, SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.3 Exploratory Research Center on Life and Living Systems (ExCELLS), NINS, Okazaki 444-8787, Japan.2 National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.1 Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.